coronary artery disease; PET; risk factors; myocardial perfusion; progression–regression CAD; Coronary atherosclerosis progresses by 2 mechanisms—gradual progressive lipid accumulation causing coronary artery stenosis or sudden plaque rupture associated with localized inflammation and thrombosis that partially or completely blocks the artery. These plaques are also called atheromatous plaques or …

Future studies will focus on identification of new disease-causing genes and susceptibility genes, exploration of the molecular mechanisms by which mutations cause coronary artery disease/myocardiaI infarction, and gene-specific therapies for patients. One multinational study showed that in-hospital death rate is significantly higher among those patients with pre-existing coronary arterial disease (10.2% vs. 5.2%) [10]. Acute Coronary Syndrome DETAILED Overview (MI, STEMI, ... Coronary Artery Disease (CAD) Anatomy, Nursing, Heart Disease, Pathophysiology, Treatment Part 1 - Duration: 19:57. It is the leading cause of death in the United States in both men and women. Genetic studies provide new insights into the pathogenesis of coronary artery disease and myocardial infarction. Atheroscler … In most developed countries, coronary artery disease (CAD), mostly caused by atherosclerosis of coronary arteries, is one of the primary causes of death. The basic mechanisms of atherosclerotic progression have been well elucidated during the last few years. From 1990s to 2000s, mortality caused by acute MI declined up to 50%. Coronary artery disease is usually caused by a build up cholesterol rich deposits or plaques on the lining inside the artery. Causes, Mechanisms, and Symptoms of Coronary Heart Disease (CHD) Coronary heart disease (CHD) is a disorder caused by constriction or inhibition of the arteries carrying blood to the heart muscle. Background. Coronary artery disease (CAD) is the most common type of heart disease. Several pathogenetic mechanisms … To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with three stages of transcriptional cis-regulation in primary human coronary artery vascular smooth muscle cells (HCASMCs). Keywords. CAD happens when the arteries that supply blood to heart muscle become hardened and narrowed. 2(4). A substantial proportion of patients with myocardial infarction (MI) have no angiographically obstructive (≥50% diameter stenosis) coronary artery disease (CAD), including approximately 7-32% of women and 6-12% of men. Coronary Artery Disease: Pathogenesis, Progression of Atherosclerosis and Risk Factors . Open J Cardiol Heart 4/7 Dis. McLaughlin MA(1), Fuster V. Author information: (1)Department of Cardiology, Mount Sinai School of Medicine, New York, NY 10029, USA. The three mechanisms for coronary artery disease progression: insights into future management. But the existing literature is limited regarding the pathogenesis of ACS in the setting of COVID-19. If the oxygen depletion is extreme, the effect may be a myocardial infarction OJCHD.000545.2018.DOI: 10.31031/OJCHD.2018.02.000545 Vome sse Risk Factors Influencing Coronary Artery Disease A risk factor can be … Coronary heart disease, disease characterized by an inadequate supply of oxygen-rich blood to the heart muscle (myocardium) because of narrowing or blocking of a coronary artery by fatty plaques (see atherosclerosis). Summary. . Background.
When the narrowing becomes severe they can lead to heart attacks.

The incidence of CAD is related with age, gender, economic, etc. 1-4 The underlying degree of CAD ranges from absolutely no detectable luminal irregularities through moderate stenosis.